SPRAVATO TREATMENT

SPRAVATO® is the first FDA-approved nasal spray medication, taken with an oral antidepressant, for treatment-resistant depression in adults (TRD) and depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions. SPRAVATO® works differently than other medications for treatment-resistant depression. Today’s most commonly used oral antidepressants are thought to treat depression by increasing levels of neurotransmitters (serotonin, norepinephrine and dopamine) in areas of the brain that affect mood. SPRAVATO® targets the N-methyl-D-aspartate (NMDA) receptor and is believed to work differently than currently available oral antidepressants.

Treatment Process

At Transforming Minds Interventional Psychiatry, our providers and staff are committed to making the Spravato treatment process easy and comfortable to all our clients. Your first visit will be a consultation where we will:

• conduct an assessment to determine if SPRAVATO® may be right for you
• verify your insurance information as part of the eligibility
• build a treatment plan with you and enroll you in the SPRAVATO® REMS Program.

After the initial consultation and approval of eligibility, our staff will work with you to schedule the appointments for Spravato treatment. SPRAVATO® (esketamine) CIII nasal spray can only be administered under the supervision of one of our providers at our treatment center. You will be monitored for side effects for at least two hours. During this time you will be in a private room and comfortably seated in a massage chair. You should expect to have your blood pressure checked periodically during the observation period, as some
people treated with SPRAVATO® have a temporary increase in blood pressure after treatment.

Dosing Frequency of Spravato Treatment

• Weeks 1-4 : Twice Weekly
• Weeks 5-8: Once weekly
• Weeks 9+ : Once every week or every two weeks

You and your provider at TRIP will decide how long you stay on SPRAVATO based on how you respond to it and how stable your response is. Your healthcare provider will determine the dosing frequency based on how you
feel.

Preparing for Treatment

• Plan for rides to and from the treatment center. You won’t be able to drive, operate machinery, or do anything where you need to be completely alert until the day after a treatment session, following a restful sleep.
• Bring a form of entertainment, like a book or playlist, for the session. A healthcare provider at the treatment center will monitor you for at least two hours after treatment.
• Avoid eating two hours before, and drinking liquids 30 minutes before the treatment session. Some patients taking SPRAVATO® may experience nausea or vomiting.
• If you take a nasal corticosteroid or nasal decongestant medicine, take these medicines at least one hour before taking SPRAVATO®